Inflammation - The Silent Killer

in Cell

There is a new clinical study showing that a supplement containing resveratrol combined with specific polyphenols suppresses the oxidative and inflammatory stress response to eating a high fat, high carbohydrate fast food meal (think burger and fries). This study has now been published in a peer-review journal. (The Journal of Clinical Endocrinology & Metabolism, doi:10.1210/jc.2010-1812).

The supplement was specifically shown to stimulate the activity of a key regulator of the body's antioxidant defense system and survival pathways, Nrf2, and induce the expression of related antioxidant genes. What exactly does this mean?

We all know that both the burger and fries have unhealthy levels of fat and salt in them and are primarily carbohydrate-rich foods. We all understand the likelihood of weight gain and higher blood pressure when consuming a diet with high concentrations of fat and carbohydrates.

But actually, the more troubling aspect of high-fat, high-carbohydrate meals is that they seem to stimulate oxidative stress and inflammation in our bodies. Oxidative stress, an imbalance between pro-oxidant molecules (too many bad guys) and antioxidant molecules (too few good guys), allows the pro-oxidant molecules to damage the lining of tissues. Once damaged, toxins contained in food find their way into the cells beneath the protective lining and disrupt the normal functioning of cells.

In response to both the excessive amounts of pro-oxidant molecules (often referred to as free radicals) and the presence of toxins, our cells emit panicked signals to the infection-fighting white blood cells to respond and neutralize the bad guys. In fact, the cells become so panicked over the invading, unhealthy substances, that they can overcompensate send out many more signals than they need to. This results in the body sending an excessive number of white blood cells to the tissues where the calls for help originate. The massive amount of white blood cells and associated fluid in which they travel cause inflammation (swelling of tissues).

Chronic inflammation makes it hard for us to move, breathe, think, digest and sleep. It is no wonder that so many people need assistance in sleeping. It also lowers our immunity to the presence of real bad guys (bacteria, fungi, viruses) because so many of our white blood cells are fighting the damage done by the food we eat (among other things) that there are not enough white blood cells to adequately kill off the microbes that make us sick. Your army of white blood cells are outnumbered and will lose the battle. Bet you didnt think that a burger and fries could cause so much damage!

To lower oxidative stress, you can either (1) stop eating so many high-fat, high-carbohydrate foods, (2) eat more antioxidant-rich foods or add antioxidant-rich dietary supplements to your daily routine or (3) both which is our recommended course of action. But what supplement will give the best result? To find out more go here
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Susan DeBrincat has 1 articles online

Susan DeBrincat, listed in "Who's Who in Medicine and HealthCare", has helped countless people achieve a better health and success over the past 35 years. Susan and her husband Ray have reached the pinnacle of success in a very short period of time in their industry. They are a true inspiration to thousands by "living the dream!" Visit her blog here:

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Inflammation - The Silent Killer

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This article was published on 2011/04/05